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How does sickle cell anemia cause anemia?

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How does sickle cell anemia cause anemia?

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Sickel cell anemia? How does sickle cell anemia affect the muscular system? What are three ways daily life is affected for those who have sickle cell anemia? How the mutation leads to the protein that no longer functions properly in a sickle cell anemia patient? What are characteristics for sickle cell disease?