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How does sickle cell anemia cause anemia?

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How does sickle cell anemia cause anemia?

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What is the equilibrium equation for sickle cell anemia? Where is the sickle cell allele found? True or false The allele for sickle cell anemia is slowly increasing in frequency in the US? How is the sickle-cell allele maintained through natural selection? How can a gene involved in sickle cell anemia different from the genes for pea plant traits that mendel studied?