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Do enzymes cause sickle cell anemia?

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Do enzymes cause sickle cell anemia?

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Sickel cell anemia? What protein is effected by the sickle cell mutation? How many mutations exists in the chromosomes of a person who has sickle cell anemia? How the mutation leads to the protein that no longer functions properly in a sickle cell anemia patient? How does sickle cell anemia affect the muscular system?